Whole genome sequencing allows scientists to elucidate the entirety of the genome of a specific organism. As the cost of DNA sequencing continues to decrease, due in large part to Next Generation Sequencing, the more affordable and cost effective whole genome sequencing becomes for researchers everywhere. Our experience in whole genome sequencing, paired with a comprehensive portfolio of sequencing platforms, allows us to provide you with the proper workflow for any project. From bacterial genomes to the human genome, we are dedicated to providing our customers with the most reliable and affordable sequencing solution possible. Feel free to contact us for more information.
- Bacterial Genomes can be sequenced for as low as $500 depending on the options needed.
- Eukaryote genomes start at $1000 in our genome service.
Benefits of Whole Genome Sequencing
- Ability to provide greater insight into personalized medicine and diagnosis
- Aid to uncover the genetic causality of rare and/or inherited diseases
- Provides researchers with a more balanced coverage in comparison to Whole Exome Sequencing
Whole-genome characterization in pedigreed non-human primates using genotyping-by-sequencing (GBS) and imputation
Rhesus macaques are widely used in biomedical research, but the application of genomic information in this species to better understand human disease is still in its infancy. Whole-genome sequence (WGS) data in large pedigreed macaque colonies could provide substantial experimental power for genetic discovery, but the collection of WGS data in large cohorts remains a formidable expense. Here, we describe a cost-effective approach that selects the most informative macaques in a pedigree for 30X WGS, followed by low-cost genotyping-by-sequencing (GBS) at 30X on the remaining macaques in order to generate sparse genotype data at high accuracy. Dense variants from the selected macaques with WGS data are then imputed into macaques having only sparse GBS data, resulting in dense genome-wide genotypes throughout the pedigree. Read More
Bimber, B. N., Raboin, M. J., Letaw, J., Nevonen, K. A., Spindel, J. E., McCouch, S. R., … Vinson, A. (2016). Whole-genome characterization in pedigreed non-human primates using genotyping-by-sequencing (GBS) and imputation. BMC Genomics, 17(1). doi:10.1186/s12864-016-2966-x