Genetic variant key to fighting MRSA
Host genetic variation can influence susceptibility and clearance of methicillin-resistant Staphylococcus aureus infections.
Study overview
Researchers identified variants in the DNA methyltransferase gene DNMT3A associated with improved resolution of MRSA bacteremia.
Sequencing approaches used
- Whole exome sequencing
- RNA sequencing
- Bisulfite sequencing
- Immune profiling assays
Impact of genomics
These findings highlight how next-generation sequencing can uncover host-pathogen interactions and inform future therapeutic strategies.
Support infectious disease research
We provide sequencing and bioinformatics for host-pathogen studies.